Georgetown University Medical Center

Staff

Section: Research Staff

RESEARCH STAFF

 Note:  All e-mail addresses are NetID@georgetown.edu

Xin (James) Li
Bioinformatician, Research Associate

Contact Information
Room 180, Building D
NetID: xl35
Telephone: (202) 687-8533

Research Interests

  • Microarray Data Storage and Analysis
  • Biomedical Workflow Management
  • Heterogeneous Database Integration
  • Web Services Oriented System Design
  • Machine Learning

Bio

Xin (James) Li received his Master’s degree in Information Systems on May 2003, from University of Maryland, Baltimore County (UMBC). Xin is also a Ph.D. candidate in the same department. He joined the department of Biostatistics, Bioinformatics and Biomathematics at Georgetown University on May 2006 as a Research Associate.

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Anne-Michelle Noone
Biostatistician, Research Associate

Contact Information
Room 103, Building D
NetID: an268
Telephone: (202) 687-2239

Research Interests

  • Survival Data Analysis
  • Phase I, II, III Cancer Clinical Trials
  • Microarray Data analysis

Bio

Anne-Michelle Noone received her M.S. degree in Biostatistics from the University of Michigan, Ann Arbor in 2005. Before joining LCCC in 2008, she worked as a Graduate Student Research Assistant where she applied machine learning methods such as classification and regression trees (CART), random forests, neural nets, and support vector machines to survival data for cancer prognostication.

Publications

Articles in Journals

  1. Movva S, Noone AM, Banerjee M, Patel D, Schwartz K, Yee CL, Simon MS (2008). Racial Differences in Cervical Cancer Survival in the Detroit Metropolitan Area. Cancer, 112; 1264-71.
  2. Kroon HM, Li Q, Teitz-Tennenbaum S, Whitfield JR, Noone AM, Chang AE (2006). 4-1BB Co-stimulation of Effector T Cells for Adoptive Immunotherapy of Cancer: Involvement of Bcl Gene Family Members. Journal of Immunotherapy, 30; 406-16.
  3. Simon MS, Banerjee M, Crossley-May H, Vigneau FD, Noone AM, Schwartz K (2006). Racial Differences in Breast Cancer Survival in the Detroit Metropolitan Area. Breast Cancer Research and Treatment, 97; 149-55.
  4. Deng HY, Zwetchenbaum S, Noone AM (2004). Bond Strength of silicone to polyurethane following immersion of silicone in cleaning solutions. Journal of Prosthetic Dentistry, 91; 582-5.

Book Chapters

  1. Noone AM, Banerjee M. (2008) Machine Learning Methods for Cancer Diagnosis and Prognostication. In R. Khattree, D. Naik (Eds.) Computational Methods in Biochemical Research (pp. 77-101). Boca Raton, FL: Chapman & Hall/CRC Biostatistics Series.
  2. Banerjee M, Noone AM. (2008) Tree-Based Methods for Survival Data. In A. Biswas, S. Datta, J. Fine, M. Segal (Eds.) Statistical Advances in Biomedical Sciences: Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics. (pp. 265-286). Hoboken, NJ: John Wiley & Sons, Inc.

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Rebecca S. Slack, MS
Biostatistician, Research Associate

Contact Information:
Suite 180 Building D
NetID: slackrs
Telephone: (202) 687-0830

Affiliations

Lombardi Comprehensive Cancer Center
• Biostatistics and Bioinformatics Shared Resource
• Clinical Research Committee
• Data Safety and Monitoring Committee

Research Interests

  • Study design and project development
  • Follow-up analyses and reports for research projects
  • Phase I, II, III cancer clinical trials
  • Vaccine therapy development in clinical trials
  • Epithelial stem cell identification and function
  • Nutritional and metabolic effects on cancer treatment response

Bio

Rebecca Slack, MS, has been a staff member in the Biostatistics & Bioinformatics Shared Resource since 1996. After teaching mathematics for 3 years, she attended Cornell University where she completed a Masters degree in Biometry in September 1996 and gained some consulting experience. Her minor was in International Nutrition with a focus in Nutritional Epidemiology. Her thesis work applied linear and nonlinear models to evaluate the process of depletion and repletion in a malnourished population across pregnancy and lactating cycles.

Courses Taught

BIST 501 - Introductory Biostatistics
BIST 502 – Applied Biostatistics
BIST 550 - Consulting

Publications

  1. Arun, B, Slack, R, Gehan, E, Spitzer, T, Meehan, K. 1999. Survival After Autologous Homatopoetic Stem Cell Transplantation for Patients with Inflammatory Breast Cancer. Cancer. 85:1 pp. 93-99.
  2. Hsu E, Bei M, Slack R, Hartzman R, Ng J, Hurley C. 1999. HLA-A*28 Allele Frequencies in the Five Major U.S. Ethnic Groups. Human Immunology 60, 159-167.
  3. Wu A, Michejda M, Mazumder A, Meehan K, Menendez F, Tchabo J-G, Slack R, Johnson M, Bellanti J. 1999. Analysis and Characterization of Hematopoietic Progenitor Cells from Fetal Bone Marrow, Adult Bone Marrow, Peripheral Blood and Cord Blood. Pediatric Research, 46:2 pp. 163-169. Needs correction.
  4. Bei M, Ng J, Slack R, Ellis J, Hartzman RJ, Hurley CK. 1999. The Relative Frequencies of HLA-A*10 Alleles in Five Major U.S. Ethnic Populations. Tissue Antigens. 54:295-299.
  5. Sintasath, DM, Tang T, Slack R, Tilley EE, Ng J, Hartzman RJ, Hurley CK. 1999. Relative HLA DRB1*13 Allele Frequencies and DRB3 Associations of Unrelated Individuals from Five U.S. Populations. Human Immunology, 60, 1001-1010.
  6. Burnett C, Steakley C, Slack R, Roth J, Lerman C. 1999. Patterns of Breast Cancer Screening Among Lesbians at Increased Risk for Breast Cancer. Women and Health, 29, 35-55.
  7. Hanfelt J, Slack R, Gehan E. 1999. A Modified Version of Simon’s Optimal Design Where the Criterion is the Median Sample Size. Controlled Clinical Trials. 20:555-566.
  8. Collins M, Tang T, Slack R, Sintasath D, Hartzmann RJ, Ng J, Hurley CK. 2000. The relative frequencies of HLA-DRB1*01 alleles in the major U.S. Populations. Tissue Antigens . 55: 48-52.
  9. Ellis J, Henson V, Slack R , Ng J, Hartzman RJ, Hurley CK. 2000. The Frequencies of HLA-A2 Alleles in Five U.S. Population Groups: Predominance of A*02011 and Identification of HLA-A*0231. Human Immunology. 61: 334-340.
  10. Kosman C, Steiner N, Pulyaeva H, Mitton W, Slack R, Hartzman RJ, Ng J, Hurley CK. 2000. The Relationship between HLA-B45 and B*5002 in the Five Major U.S. Population Groups. Tissue Antigens. 55: 437-442.
  11. Pimtanothai N, Rizzuto GA, Slack R, Steiner NK, Kosman CA, Jones PF, Koester R, Ng J, Hartzman R, Hurley CK. 2000. The Diversity of Alleles Encoding HLA-B40: The relative Frequencies in U.S. Populations and Description of Five Novel Alleles. Human Immunology. 61(8): 808-815.
  12. Tang T, Huang A, Pappas A, Slack R, Ng J, Hartzman RJ, Hurley C. 2000. Relative Frequencies of DRB1*11 Alleles and their DRB3 Associations in Five Major Population Groups in the United States. Human Immunology. 61(8): 820-827.
  13. Yang X, Wei L, Tang C, Slack R, Montgomery E, Lippman M. 2000. KAI1 Protein is Down- Regulated During the Progression of Human Breast Cancer. Clinical Cancer Research. 6(9):3424-3429.
  14. Bowen C, Bubendorf L, Voeller HJ, Slack R, Willi N, Sauter G, Gasser TC, Koivisto P, Lack EE, Kononen J, Kallioniemi O, Gelmann EP. 2000. Loss of NKX3.1 Expression in Human Prostate Cancers Correlates with Tumor Progression. Cancer Research. 60(21):6111-6115.
  15. Houtenbous I, Bracho F, Davenport V, Slack R, Van de Ven C, Suen Y, Killen R, Shen V, Sender L, and Cairo M. 2001. Autologous bone marrow transplantation for childhood acute lymphoblastic leukemia: a novel combined approach consisting of ex vivo marrow purging, modulation of multi-drug resistance, induction of auto graft vs leukemia effect and post transplant immuno and chemotherapy. Bone Marrow Transplant. 27(2):145-53.)
  16. Meehan KR, Wu A, Hassan R, Miao Y, Chawla J, Slack R, Gehan E, Herscowitz HB. 2001. Ex Vivo Cytokine Activation of Peripheral Blood Stem Cells: A Potential Role for Adoptive Cellular Immunotherapy. J of Hematotherapy & Stem Cell Research. 10:283-290.
  17. Goldman SC, Bracho F, Davenport V, Slack R, Areman E, Shen V, Lenarsky C, Weinthal J, Hughes R, Cairo MS. 2001. A Feasibility Study of Interleukin-11 and G-CSF following myelosuppressive chemotherapy to mobilize peripheral blood stem cells (DC34 +) from heavily pretreated patients. Am J Pediatr Hematol Oncol. 23(5): 300-305.
  18. Yang X, Wei L, Tang C, Slack R, Mueller M, Lippman M. 2001. Overexpression of KAI1 Suppresses In Vitro Invasiveness and In Vivo Metastasis in Breast Cancer Cells. Cancer Research. 16 (13):5284-8.
  19. Stearns V, Ewing CA, Slack R, Penannen MF, Hayes DF, Tsangaris TN. 2002. Sentinel Lymphadenectomy After Neoadjuvant Chemotherapy for Breast Cancer May Reliably Represent the Axilla Except for Inflammatory Breast Cancer. Annals of Surgical Oncology, 9 (3): 235-242.
  20. Abu-Ghosh AM, Krailo MD, Goldman SC, Slack RS, Davenport VG, Morris EK, Laver JH, Reaman GH, Cairo MS. 2002. Ifosfamide, Carboplatin, and Etoposide in Children with Poor-Risk Relapsed Wilm’s Tumor: A Children’s Cancer Group (CCG) Report. Annals of Oncology 13: 460-469.
  21. Meehan K, Slack R, Gehan E, Herscowitz H, Areman E, Ebadi M, Cairo M, Lippman M. 2002. Mobilization of peripheral blood stem cells with paclitaxel and rhG-CSF in high-risk breast cancer patients. Journal of Hematotherapy and Stem Cell Research, 11(2):415-421.
  22. Gans CP, Tang TF, Slack R, Ng J, Hartzman RJ, and Hurley CK. 2002 DRB1*14 Diversitiy and DRB3 Associations in Four Major Population Groups in the United States. Tissue Antigens, 59(5):364-9.
  23. Chen DS, Tang TF, Pulyaeva H, Slack R, Tu B, Wagage D, Noreen H, Perlee L, Ng J, Hartzman RJ, Hurley CK. 2002. Relative HLA- DRB1*04 Allele Frequencies in the Five Major Populations in the United States and Six New DRB1*04 Alleles. Human Immunology, 63(8):665-72.
  24. Stearns V, Singh B, Tsangaris T, Crawford J, Novielli A, Ellis MJ, Isaacs C, Pennanen M, Tibery C, Farhad A, Slack R, Hayes DF. 2003. A Prospective Randomized Pilot Study to Evaluate Predictors of Response in Serial Core Biopsies to Single Agent Neoadjuvant Doxorubicin or Paclitaxel for Patients with Locally Advanced Breast Cancer. Clinical Cancer Research, 9:124-133.
  25. Baldassarre LA, Steiner NK, Jones P, Tang T, Slack R, Ng J, Hartzman RJ, Hurley CK. 2003. Limited diversity of HLA-DRB1*02 Alleles and DRB1-DRB5 haplotype associations in four United States populations groups. Tissue Antigens, 61: 249-252.
  26. Rizzuto G, Li L, Steiner N, Slack R, Tang T, Heine U, Lin Y, Ng J, Hartzman RJ, Hurley CK. 2003. Diversity Within the DRB1*08 Allele Family In Four Populations From A United States Hematopoietic Stem Cell Donor Database And Characterization Of Five Novel DRB1*08 Alleles. Human Immunology, 64: 607-613.
  27. Han Z, Slack RS, Li W, Papadopoulos V. 2003. Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression. J Recept Signal Transduct Res. 23(2-3):225-38.
  28. Pack SD, Alper OM, Stromberg K, Augustus M, Ozdemirli M, Miermont AM, Klus G, Rusin M, Slack R, Gacker NF, Ried T, Szallasi Z, Alper O. 2004. Simultaneous Suppression of EGFR and c-erbB-2 Reverses Aneuploidy and Malignant Phenotype of a Human Ovarian Carcinoma Cell Line. Cancer Research. 1;64(3):789-94.
  29. Marshall JL, Gulley JL, Arlen P, Beetham PK, Tsang K-Y, Slack R, Hodge JW, Doren S, Grosenbach DW, Hwang J, Fox E, Odogwu L, Park S, Panicali D, Schlom J. 2005. Phase I Study of Sequential Vaccinations with Fowlpox-CEA(6D)-TRICOM Alone and Sequentially With Vaccinica-CEA(6D)-TRICOM, With and Without Granulocyte-Macrophage Colony-Stimulating Factor, in Patients with Carcinoembryonic Antigen-Expressing Carcinomas. Journal of Clinical Oncology. 23(4):1-12.
  30. Chepko G, Slack R, Carbott D, Kahn S, Stedman L, Dickson RB. 2005. Cell Type Population Sizes and Cell Cycle Activity are Differentially Altered in Ducts and Lobues of TGFα and c-Myc Transgenic Mouse Mammary Epithelium. Tissue and Cell. 37: 393-412.
  31. Isaacs C, Slack RS, Gehan EA, Ballen K, Boccia R, Areman E, Hayes DF, Herscowitz H, Lippman M. 2005. A Multicenter Randomized Clinical Trial Evaluating Interleukin-2 Activated Hematopoietic Stem Cell Transplantation and Post-transplant IL-2 for High Risk Breast Cancer Patients. Breast Cancer Research and Treatment. 93: 125-134. (.pdf)
  32. Stearns V, Slack R, Greep N, Henry-Tilman R, Osborne M, Bunnel C, Ullmer L, Gallagher A, Cullen J, Gehan EA, Hayes DF, Isaacs C. 2005. Paroxetine Is An Effective Treatment For Hot Flashes: Results From A Prospective Randomized Clinical Trial. Journal of Clinical Oncology. 23(28):6919-6930. (.pdf)
  33. Bowden, E.T., Onikoyi, E., Slack, R., Myoui, A., Yoneda, T., Yamada, K.M. (2006) Co-localization of Cortactin and Phosphotyrosine Identifies Active Invadopodia in Human Breast Cancer Cells. Experimental Cell Research. 312, 1240-1253.
  34. Lazaro, A.M., Steiner, N.K., Cao, K., Slack, R., Chen, D.S., Xiao, Y., Beduhn, E., Ng, J., Hartzman, R.J., Hurley, C.K. (2006) Searching for HLA-DRB1*1206 in Volunteer Marrow Donors in Four US Population Groups. Tissue Antigens. 68, 439-441.
  35. White, A.M., Banovac. F., Yousefi, S., Slack, R.S., Spies, J.B. (2007) Uterine Fibroid Embolization: The Utility of Aortography in Detecting Ovarian Artery Collateral Supply. Radiology. 244, 291-298.

 

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