Georgetown University Medical Center

Secondary Appointments

Section: Secondary Appointments

Lin (Limin) Clegg, Ph.D.
Adjunct Professor

Contact Information
Office of Healthcare Inspections, Office of Inspector General
U. S. Department of Veterans Affairs
801 I street, NW
Washington, DC 20001
NetID: lc535
Telephone: (202) 565-8471

Bio

Dr. Lin Clegg received her Doctor of Philosophy in Biostatistics in May 1997, from University of North Carolina at Chapel Hill. She received her Master of Science in Textile Engineering from China National Textile University. Over the years, Dr. Clegg has been working with cancer survival data and tissue microarrays, and developed methodologies to analyze these types of data. In addition to joining the Department of Biostatistics, Dr. Clegg currently serves as a Senior Mathematical Statistician at the U.S. Department of Veterans Affairs. She has recently been appointed as an Adjunct Professor of Biostatistics.

Publications

  1. Clegg LX, Reichman ME, Hankey BF, Miller BA, Lin YD, Johnson NJ, Schwartz SM, Bernstein L, Chen VW, Goodman MT, Gomez SL, Graff JJ, Lynch CF, Lin CC, Edwards BK. (2007). Quality of race, Hispanic ethnicity, and immigrant status in population-based cancer registry data: implications for health disparity studies. Cancer Causes and Control 18:177-187.
  2. Tiwari RC, Clegg LX, Zou Z (2006). Efficient interval estimation for age-adjusted cancer rates. Statistical Methods in Medical Research 15:547-569.
  3. Harlan LC, Clegg LX, Abrams J, Stevens JL, Ballard-Barbash R. (2006) Community based use of chemotherapy and hormonal therapy for early stage breast cancer: 1987-2000. Journal of Clinic Oncology 24:872-877.
  4. Gigli A, Mariotto A, Clegg LX, Tavilla A, Corazziari I, Hachey M, Scoppa S, Capocaccia A. (2006) Estimating the variance of cancer prevalence from population-based registries. Statistical Methods in Medical Research 15:235-253.
  5. Cronin DP, Harlan LC, Potosky AL, Clegg LX, Stevens JL, Mooney MM. (2006) Patterns of care for adjuvant therapy in random population-based sample of patients diagnosed with colorectal cancer. American Journal of Gastroenterology 101:2308–2318.
  6. Harlan LC, Green AL, Clegg LX, Mooney M, Stevens JL, Brown ML. Insurance status and the use of guideline therapy in the treatment of selected cancers (2005). Journal of Clinic Oncology 23:9079-9088.
  7. Cronin DP, Harlan LC, Clegg LX, Stevens JL, Davis TA. (2005) Patterns of care in a population-based random sample of patients diagnosed with Non-Hodgkin’s lymphoma. Hematological Oncology 23:73-81.
  8. Midthune DN, Fay MP, Clegg LX, Feuer EJ. (2005) Modeling reporting delays and reporting corrections in cancer registry data. Journal of American Statistical Association 100:61-70.
  9. Trimble EL, Harlan LC, Clegg LX., Stevens JL. (2005) Pre-operative imaging, surgery and adjuvant therapy for women diagnosed with cancer of the corpus uteri in community practice in the United States. Gynecologic Oncology 96:741-748.
  10. Trimble EL, Harlan LC, Clegg LX. (2005) Untreated cervical cancer in the United States. Gynecological Oncology 96:271-277.
  11. Hernandez BY, Frierson HF, Moskaluk CA, Li YJ, Clegg LX, Cote TR, McCusker ME, Hankey BF, Edwards BK, Goodman MT (2005). CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray. Human Pathology 36:275-281.
  12. Goodman MT, Hernandez BY, Hewitt S, Lynch CF, Coté TR, Frierson Jr HF, Moskaluk CA, Killeen JL, Cozen W, Lynch CF, Key CR, Clegg LX, Reichman M, Hankey BF, Edwards BK. (2005) Tissues from population-based cancer registries: a novel approach to increasing research potential. Human Pathology 36:812-820.
  13. Jemal A, Clegg LX, Ward E, Ries LAG, Wu X, Jamison PM, Wingo PA, Howe HL, Anderson RN, Edwards BK. (2004) Annual report to the nation on the status of cancer, 1975-2001, with a special feature on survival. Cancer 101:3-27.
  14. Clegg LX, Li FP, Hankey BF, Chu K, Edwards BK. (2003) Cancer survival in US racial/ethnic groups: heterogeneity among Asian ethnic subgroups. Archives of Internal Medicine 163:632.
  15. Harlan LC, Clegg LX, Trimble EL. (2003) Trends in surgery and chemotherapy for women diagnosed with ovarian cancer in the U.S. Journal of Clinical Oncology 21:3488-3494.
  16. Agelli M, Clegg LX. (2003) Epidemiology of primary Merkel cell carcinoma in the United States. Journal of the American Academy of Dermatology 49: 832-841. (Erratum in: Journal of the American Academy of Dermatology (2004) 50:733).
  17. Harlan LC, Clegg LX, Warren J. (2003). Chemotherapy in women with breast cancer. Annals of Internal Medicine 139: 868.
  18. McCusker ME, Coté TR, Clegg LX, Tavassoli FJ. (2003) Endocrine tumors of the uterine cervix: Incidence, demographics and survival with comparison to squamous cell carcinoma. Gynecologic Oncology 88: 333-339.
  19. Clegg LX, Gail MH, Feuer EJ. (2002) Estimating the variance of disease prevalence estimates from population-based registries. Biometrics 58:684-688.
  20. Clegg LX, Feuer EJ, Midthune DN, Fay MP, Hankey BF. (2002) Impact of reporting delay and reporting error on cancer incidence rates and trends. Journal of the National Cancer Institute 94:1537-1545.
  21. Clegg LX, Li FP, Hankey BF, Chu K, Edwards BK. (2002) Cancer survival among US whites and minorities: A SEER (Surveillance, Epidemiology and End Results) population-based study. Archives of Internal Medicine 162:1985-1993.
  22. McNeil DE, Coté TR, Clegg LX, Rorke LB. (2002) Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: A SEER update. Medical and Pediatric Oncology 39:190-194.
  23. Potosky AL, Reeve BB, Clegg LX, Hoffman RM, Stephenson RA, Albertsen PC, Gilliland FD, Stanford JL. (2002) Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy. Journal of the National Cancer Institute 94:430–437.
  24. Harlan LC, Abrams J, Warren J, Clegg LX, Stevens J, Ballard-Barbash R. (2002) Adjuvant therapy for breast cancer – practice patterns of community physicians. Journal of Clinical Oncology 20: 1809-1817.
  25. McCusker ME, Coté TR, Clegg LX, Sobin LH. (2002) Primary malignant neoplasms of the appendix: A population-based study from the surveillance, epidemiology and end-results program, 1973-1998. Cancer 94:3307-12.
  26. McNeil DE, Coté TR, Clegg LX, Mauer A. (2002) SEER update of incidence and trends in pediatric malignancies: acute lymphoblastic leukemia. Medical and Pediatric Oncology 39:554-7; discussion 552-3.
  27. Mariotto A, Capocaccia R, Verdecchia A, Micheli A, Feuer EJ, Pickle L, Clegg LX. (2002) Projecting SEER cancer survival rates to the US: An ecological regression approach. Cancer Causes and Control 13: 101-111.
  28. Clegg, LX, Potosky, AL, Harlan LC, Hankey BF, Hoffman RM, Stanford JL, Hamilton AS. (2001) Comparison of self-reported initial treatment with medical records: Results from the Prostate Cancer Outcomes Study. American Journal of Epidemiology 154:582-587.
  29. Potosky AL, Knopf K, Clegg LX, Albertsen PC, Stanford JL, Hamilton AS, Gilliland FD, Eley JW, Stephenson RA, Hoffman RM. (2001) Quality-of-life outcomes after primary androgen deprivation therapy: results from the Prostate Cancer Outcomes Study. Journal of clinical Oncology 19:3750-3757.
  30. Clegg LX, Cai J, Sen PK, Kupper LL. (2000) Misspecification of marginal hazards models in multivariate failure time data. Sankhya: The Indian Journal of Statistics. Ser. B 62:25-42.
  31. Clegg LX, Cai J, Sen PK. (2000) Modeling multivariate failure time data. In Handbook of Statistics, Volume 18: Bioenvironmental and Public Health Statistics (Editors: C. R. Rao and P. K. Sen): 803-838.
  32. Chambless LE, Folsom A, Clegg LX, Sharrett AR, Eyal S, Rosamond WD, Evans G. (2000) Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) Study. American Journal of Epidemiology 151:478-487.
  33. Hankey BF, Ries L, Kosary CL, Feuer EJ, Merrill RM, Clegg LX, Edwards BK. (2000). Partitioning linear trends in age-adjusted rates. Cancer Causes and Control 11: 31-35.
  34. Clegg LX, Cai J, Sen PK. (1999). A marginal mixed baseline hazards model for multivariate failure time data. Biometrics 55: 805-812.
  35. Hankey BF, Feuer EJ, Clegg LX, Hayes RB, Legler JM, Prorok PC, Ries LA, Merrill RM, Kaplan RS. (1999). Interpreting trends in prostate cancer Part I: Evidence of the effects of screening in recent prostate cancer incidence, mortality, and survival rates. Journal of National Cancer Institute 91:1017-1024.
  36. Klein R, Clegg LX, Cooper LS, Hubbard LD, Klein BEK, King WN, Folsom AR. (1999) The prevalence of age related maculopathy in the Atherosclerosis Risk in Communities Study. Archives of Ophthalmology 117: 1203-1210.
  37. Hubbard LD, Brothers R, King WN, Clegg LX, Klein R, Cooper LS, Sharrett AR, Davis MD, Cai J. (1999) Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the ARIC. Ophthalmology 106: 2269-2280.
  38. Rosamond WD, Chambless LE, Folsom AR, Clegg LX, Wang CH, Heiss G. (1998) Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994. New England Journal of Medicine 339: 861 867.
  39. Weitzman S, Cooper L, Chambless L, Rosamond W, Clegg LX, Marcucci G, Romm F. (1997) Gender, racial and geographic differences in the performance of cardiac diagnostic and therapeutic procedures for hospitalized myocardial infarctions in four states. American Journal of Cardiology 79: 722 726.
  40. Folsom AR, Arnett DK, Hutchinson RG, Liao F, Clegg LX, Cooper LS. (1997) Physical activity and incidence of coronary heart disease in middle aged women and men. Medicine and Science in Sports and Exercises 29: 901 909.
  41. Chambless LE, Heiss G, Folsom AR, Rosamond WD, Szklo M, Sharrett AR, Clegg LX. (1997) Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study. American Journal of Epidemiology 146: 483 494.
  42. Oakland BG, Dodd RB, Schabacker DJ, Clegg LX. (1992) Preliminary evaluation of nonwoven chemically treated barrier fabrics for field testing of protective clothing for agricultural workers exposed to pesticides. Bull Environ Contam Toxicology 49: 51-57.
  43. Yabroff KR, Harlan LC, Clegg LX, Ballard-Barbash R, Stevens J, Weaver DL, Donald L. (2007) Is mode of breast cancer detection associated with cancer treatment in the United States? Cancer (in press).
  44. Cronin-Fenton DP, Ries LA, Clegg LX, Edwards BK. (2007) Rising incidence rates of breast carcinoma with micro-metastatic lymph node involvement. Journal of the National Cancer Institute 99: 1044 – 1049.

Review/Editorials in Refereed Journals

  1. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Mariotto A, Feuer EJ, Edwards BK (2006). SEER Cancer Statistics Review, 1975-2003. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2003.
  2. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Mariotto A, Feuer EJ, Edwards BK (2005). SEER Cancer Statistics Review, 1975-2002. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2002.
  3. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Mariotto A, Feuer EJ, Edwards BK (2004). SEER Cancer Statistics Review, 1975-2001. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2001.
  4. Cronin K, Mariotto A, Scoppa S, Green D, Clegg LX. (2003). Differences between brenner et al. and nci methods for calculating period survival. Technical Report # 2003-02, Statistical Research and Applications Branch, National Cancer Institute.
  5. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Mariotto A, Fay MP, Feuer EJ, Edwards BK. (2003). SEER Cancer Statistics Review, 1975-2000. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2000.
  6. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK. (2002) SEER Cancer Statistics Review, 1973-1999. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1973_1999.
  7. Mariotto A, Gigli A, Capocaccia R, Tavilla A, Clegg LX., Depry M, Scoppa S, Ries LAG, Rowland JH, Tesauro G, Feuer EJ. (2002). Complete and limited duration cancer prevalence estimates in Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK. (eds). SEER Cancer Statistics Review, 1973-1999. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1973_1999.
  8. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK. (2001) SEER Cancer Statistics Review, 1973-1998. National Cancer Institute. Bethesda, MD.
  9. Clegg LX, Midthune DN, Feuer EJ, Fay MP, Hankey BF. Cancer incidence rates adjusted for reporting delay (2000) in Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK. (eds) SEER Statistics Review, 1973-1997. National Cancer Institute. Bethesda, MD.
  10. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK. (2000) SEER Statistics Review, 1973-1997. National Cancer Institute. NIH Pub. No. 00-. Bethesda, MD.
  11. Ries LAG, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK. (1999) SEER Statistics Review, 1973-1996. National Cancer Institute. NIH Pub. No. 99-2789. Bethesda, MD.
  12. Clegg LX. (1997) Marginal models for multivariate failure time data with generalized dependence structure. Institute of Statistics Mimeo Series No. 2184T, University of North Carolina at Chapel Hill.
  13. Clegg LX, Cai J, Sen PK. Marginal models for failure time data with generalized dependence structure. Proceedings of the Joint Statistical Meetings in Chicago, 1996.

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Christopher Loffredo, PhD
Associate Professor of Oncology & Biostatistics

Contact Information
LL Lombardi
NetID:cal9
Telephone: (202) 687-3758

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Rochelle Tractenberg, MPH, PhD
Assistant Professor

Contact Information
Room 291, Building D
NetID: ret7
Telephone: (202) 687-2247

Affiliations

Memory Disorders Program
Department of Psychiatry
DC Clinical Research Training Consortium

Bio

Dr. Tractenberg is an assistant professor in the Department of Neurology, with secondary appointments in Biostatistics, Bioinformatics & Biomathematics and Psychiatry, in the Georgetown University School of Medicine. She has authored or co-authored nearly 50 peer-reviewed papers/chapters/articles on research methodologies, outcomes, and analytic methods, and also has an active research program in the scholarship of teaching and learning. She was named Editor for Science and Technology for the online journal Academic Intersections when it was founded in 2006, and in 2008 was named to the Associate Editorial Board for the journal Contemporary Clinical Trials, with specific responsibility for articles on “Protocols and Statistical Design”. She oversaw biostatistical analysis and experimental design for the Georgetown General Clinical Research Center (GCRC) 2003-2006 as the Consulting Biostatistician, and is currently the Director of the Curriculum for the NCRR-funded DC Consortium for Clinical Training Research (2005-2010). Dr. Tractenberg has a five-year K01 mentored training grant (2006-2011) from NIA to study latent variable modeling and neuropsychology in aging. Named an Apple Distinguished Educator in 2004, she is a member of the Faculty Development Committee, where she chaired the Subcommittee on the Teaching Portfolio (2005-06) and currently co-chairs the Subcommittee on Teaching and Pedagogy for the Faculty Development Committee. Her areas of interest include statistical methodology and pedagogy in statistics, as well as neuropsychological instrumentation, identification of outcomes, experimental design, and longitudinal analytic methodologies, particularly latent variable methods. Prior to coming to Georgetown, Dr. Tractenberg spent five years at the University of California at San Diego as a biostatistician and scientist within a national consortium of Alzheimer's disease research centers.

Research Interests

My main interests in terms of cognitive neuroscience are a) understanding how symptoms of Alzheimer’s disease (e.g., behavioural disturbance, cognitive decline, sleep disturbance) can be accurately ‘measured’ and what, in the brain, these symptoms actually reflect; and b) understanding how inaccuracies in these measurements affect statistical modeling and by extension, our conceptualization of the symptoms themselves. In terms of statistical modeling, I am interested in how latent variable modeling techniques can improve the power, efficiency, and interpretability of clinical and translational research. Since 2007 I have been working on latent variable modeling of hypertension, emphasizing animal models and how results from this approach can be translated to models of hypertension in humans. In terms of cognitive science, I am interested in modeling executive function, which basically controls cognitive functions like attention and memory. Executive function likely has an important role in health literacy, which is another research area of mine. I am also very interested in the graduate student experience, how to teach or at least encourage creativity and metacognition, and assessment in the postgraduate setting.

Research Summary: I have three main research trajectories: 1. measurement in neuropsychology (e.g., what we think we’re measuring and how to find out if we are right) and how assumptions affect statistical modeling of neuropsychological phenomena such as ‘cognitive decline’ and ‘behavioural disturbance’; 2. developing a model of sleep disturbance and depression in elderly persons with and without Alzheimer’s disease; and 3. understanding how causal models and latent variable models and methods can be used defensibly and efficiently in clinical and translational research. My research is mainly methodological: I am interested in how and why we measure certain aspects of important cognitive, behavioural, and symptom-specific domains, and the sources of error in these measurements. Eventually, I want to bring this knowledge to a study of the neurophysiologic origins of our measurements, that is, how what we measure is reflected in the brain and its activity. Similarly, by performing item-level analyses of the associations between symptoms of sleep and mood disturbance, with my colleagues I hope to develop a framework for a better understanding of their relationships and their underlying neurophysiology; this will be accomplished with latent variable models.

Teaching

Dr. Tractenberg helped to re-design the introductory biostatistics course that was mandated for GU graduate students in the School of Medicine in 2004, and has taught introductory biostatistics at GU to graduate students and at the FDA to Scientific Leadership Program participants. She is the course director for Introductory Biostatistics (BIST 500-01) and Issues and Considerations in Experimental Design (BIST 500-2) and has developed a course on outcomes (BIST 507) to be offered in Spring semesters starting in 2009. Professor Tractenberg helped design the curriculum for the DC Clinical Research Training Consortium (the curriculum which she Directs), consults with faculty in the analysis and interpretation of test scores, and will offer a workshop at the Teaching, Learning and Innovations Summer Institute that focuses on item and test score analysis and interpretation.

Publications

  1. Nissman S, Tractenberg RE, Babbar-Goel, A and Pasternak JF. (2008). Oral gabapentin for the treatment of postoperative pain following photorefractive keratectomy: a clinical trial. American Journal of Ophthalmology doi:10.1016/j.ajo.2007.11.012.
  2. Tractenberg, R. E., Aisen P. S., Hancock, G. R., and Rebeck, G. W. (2007). No cross-sectional influence of APOE ε4 dose on clinical tests in Alzheimer's disease. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2007.11.006.
  3. Saunders P, Tractenberg RE, Chaterji R, Amri H, Harazduk N, Gordon JS, Lumpkin M, and Haramati A. (2007). Mind-Body Skills in first year medical students: perceptions and attitudes. Medical Teacher 29(8):778-84.
  4. Tractenberg RE and Freas CE. (2007) Benchmarking a computerized test of immediate verbal memory. Behavior Research Methods 39(4):863-9.
  5. Chaterji, R., Tractenberg, R. E., Lumpkin, M., and Haramati, A. (2007). A large-sample survey of 1st and 2nd year medical student attitudes toward Complementary and Alternative Medicine in the curriculum and practice. Alternative Therapies in Health and Medicine 13(1): 30-35.
  6. Tractenberg, R. E., Chaterji, R., and Haramati, A. (2007). Assessing and analyzing change in attitudes in the classroom. Assessment and Evaluation in Higher Education. 32(2): 107-120.
  7. Tractenberg, R. E., Weiner, M. F., Aisen, P. S., Kaye, J. A. and Fuh, J-L. (2007). A simple method to rule out dementia in community-based cohorts. Alzheimer’s and Dementia. 3(10): 28-32.
  8. Tractenberg, R. E., Weiner, M. F., and Chuang, Y-L. (2007) CES-D symptoms and DSM criteria: Levels of depressive symptomatology in a cohort of Taiwanese elderly. Journal of Chinese Clinical Medicine 2(1): 1-10.
  9. Holst JP, Soldin SJ, Tractenberg RE, Guo T, Kundra P, Verbalis JG and Jonklaas J. (2006). Use of Steroid Profiles in the Determining the Cause of Adrenal Insufficiency. Steroids 72:71-84.
  10. Kaltman, S., Tractenberg, R. E., Taylor, K., and Green, B. L. (2006). Modeling dimensions of complex medical decisions: The smallpox vaccine. American Journal of Health Behavior. 30(5): 513-24.
  11. Kaltman, S., Tractenberg, R. E., Taylor, K., and Green, B. L. (2006). The Smallpox Vaccine: A Five-Dimensional Model of Choice. Biosecurity and Bioterrorism 4(1):64-73.
  12. Lungeanu D, Tractenberg RE and Mihalas GI. (2006). Developing an Interactive Approach in Teaching Medical Informatics. Studies in health technology and informatics (Proceedings of the 20th International Congress of the European Federation for Medical Informatics (August 2006). IOS Press. Vol 124:885-890.
  13. Nissman, S.A., Tractenberg, R.E., Saba ,S.M., and Lustbader, J.M. (2006). The accuracy, repeatability and clinical application of spherocylindrical automated refraction using time-based wavefront aberrometry measurements. Ophthalmology 113: 570-77.
  14. Tractenberg RE, Aisen PS, Weiner MF, Cummings JL, Hancock GR. (2006). Independent contributions of neural and 'higher order' deficits to symptoms in Alzheimer’s disease: a latent variable modeling approach. Alzheimer’s and Dementia 2(4):303-313.
  15. Tractenberg, R. E., Singer C. M., and Kaye J. A. (2006). Characterizing sleep disturbance in elderly normal and AD. Journal of Sleep Research 14: 177-185.
  16. Tractenberg,R. E., Aisen, P., and Chuang, Y-L.(2005). One trial 10-item free recall performance in Taiwanese elderly and near-elderly:a potential screen for cognitive decline. American Journal of Alzheimer’s Disease and Other Dementias.20(4):239-47.
  17. Soldin O.P., Tractenberg, R.E., and Pezzullo, J. (2005). Do Thyroxine and Thyroid Stimulating Hormone Levels Reflect Urinary Iodine Concentrations? Therapeutic Drug Monitoring 27(2):178-185.
  18. Tractenberg, R. E., Singer, C. M., and Kaye, J. A. (2005). Symptoms of sleep disturbance in persons with Alzheimer's disease and normal elderly. Journal of Sleep Research 14: 177-85.
  19. Tractenberg, R. E., Weiner, M. F., Cummings, J. L., and Thal L. J. (2005). Independence of changes in behavior from changes in cognition and function in persons with Alzheimer’s disease: A factor-analytic approach. J Neuropsychiatry and Clin Neurosci. 17(1):51-60.
  20. Tractenberg, R. E., Weinstein, M., Weiner, M. F., Aisen, P. S., Fuh, J-L., Goldman, N., and Chuang, Y-L. (2005). Benchmarking a test of temporal orientation with data from American and Taiwanese persons with Alzheimer's disease and American normal elderly. Neuroepidemiology; 24(1-2):110-116.
  21. Cummings, J. L., Tractenberg, R. E., Gamst, A., Teri, L., Masterman, D., and Thal., L. J. (2004). Clinical trial of the treatment of agitation in Alzheimer’s disease: Interpretation of changes in the placebo group. Current Alzheimer’s Research 1:323-328.
  22. Schafer, K., Tractenberg, R. E., Sano, M., Mackell, J. A., Thomas, R. G., Thal, L. J. and Morris, J. C. (2004). Reliability of monitoring the Clinical Dementia Rating in multicenter clinical trials. Alzheimers Disease and Associated Disorders 18(4):219-22.
  23. Soldin, O. P., Tractenberg, R. E., Soldin, S. J. (2004). Differences Between Measurements of T4 and T3 in Pregnancy and in Non-Pregnant Women Using Isotope Dilution Tandem Mass Spectrometry and Immunoassays: Are There Clinical Implications? Clini Chim Acta 347: 61-69.
  24. Soldin O.P., Tractenberg R.E., Hollowell J.G., Jonklaas J., Janicic N., and Soldin S.J. (2004). Trimester-Specific Changes in Maternal Thyroid Hormone, TSH and Thyroglobulin Concentrations During Gestation: Trends and Associations Across Trimesters in Iodine Sufficiency. Thyroid. 14(12):1084-90.
  25. Swanberg, M. M., Tractenberg, R. E., Mohs R., Thal, L. J., and Cummings J. L. (2004). Executive dysfunction in Alzheimer’s disease. Archives of Neurology 61(4):556-60.
  26. Tractenberg, R. E., Singer C. S., Cummings J. L. and Thal L. J. (2003). The Sleep Disorders Inventory (SDI): An instrument for studying sleep disturbance in persons with Alzheimer’s disease. Journal of Sleep Research 12:331-337.
  27. Polianova, M. T., Ruscetti, F. W., Pert, C. B. , Tractenberg, R. E. , Leoung, G. , Strang, S. , and Ruff, M. R. (2003). Antiviral and immunological benefits in HIV patients receiving intranasal Peptide T (DAPTA). Peptides 24:1093-1098.
  28. Singer, C., Tractenberg, R.E., Kaye, J., Gamst, A., Grundman, M., Thomas, R. G., and Thal, L. J. (2003). A multicenter clinical trial of melatonin for sleep disturbance in Alzheimer’s disease. Sleep 26(97): 893-901.
  29. Tractenberg, R. E., Weiner M., F., Schneider, L., Patterson, M. B., and Thal, L. J. (2003). Comorbidity of psychopathologic domains in persons with Alzheimer’s disease. J Geriatric Psychiatry Neurol 16(2): 94-99.
  30. Tractenberg, R. E., Gamst, A., Thomas, R. G., Patterson, M. B., Schneider, L. S. and Thal, L. J. (2002). Investigating emergent symptomatology as an outcome measure in a behavioral study of Alzheimer’s disease. J Neuropsychiatry and Clin Neurosci 14(3): 303-310.
  31. Tractenberg, R. E. (2002). Exploring hypotheses about phonological awareness, memory, and reading achievement. Journal of Learning Disabilities 35(5): 407-424.
  32. Tractenberg, R. E., Weiner, M. F., and Thal, L. J. (2002). Estimating the prevalence of agitation and behavioral disturbance in community-dwelling persons with Alzheimer's disease. J Neuropsychiatry and Clin Neurosci. Winter; 14(1):11-18.
  33. Tractenberg, R. E., Weiner, M. F., Patterson, M., Schneider, L., and Thal, L. J. (2002). Emergent psychopathology in Alzheimer’s disease patients over 12 months associated with functional, not cognitive, changes. J Geriatric Psychiatry Neurol, 15(2): 110-117.
  34. Weiner, M. F., Tractenberg, R. E., Jin S., Gamst A. Thomas, R. G., Koss E., and Thal, L. J. (2002). Assessing Alzheimer’s disease patients with the Cohen-Mansfield Agitation Inventory: Scoring and clinical implications. Journal of Psychiatric Research, 36: 19-25.
  35. Weiner, M. F., Tractenberg, R. E., Sano, M., Logsdon, R., Teri, L., Galasko, D., Gamst, A., Thomas, R., and Thal, L. J. (2002). No long-term effect of behavioral treatment on psychotropic use for agitation in Alzheimer’s disease patients. Journal of Geriatric Psychiatry and Neurology, 15(2): 95-98.
  36. Tractenberg, R. E. (2001). Exploring a new silent test of phonological sensitivity. Reading and Writing: An Interdisciplinary Journal, 14(3/4):195-228.
  37. Tractenberg, R. E., Gamst, A., Weiner, M. F., Koss, E., Thomas R.G., Teri, L., and Thal L. J. (2001). Frequency of behavioral symptoms characterizes agitation in Alzheimer’s disease. International Journal of Geriatric Psychiatry,16: 886-891.
  38. Tractenberg, R. E., Schafer, K., and Morris, J. C. (2001). Inter-observer disagreement on Clinical Dementia Rating (CDR) assessments: Implications for training. Alzheimers Disease and Associated Disorders, 15: 155-161.
  39. Teri, L., Logsdon, R. G., Peskind, E., Raskind, M., Weiner, M. F., Tractenberg, R. E., et al. (2000). Treatment of agitation in Alzheimer's disease patients: A randomized placebo controlled clinical trial. Neurology, 55:1271-1278.
  40. Tractenberg, R. E., Jin S., Patterson, M., Schneider, L. S., Gamst, A. G., et al. (2000). Qualifying change: A method for defining ‘clinically-meaningful’ outcomes of change score computation. Journal of the American Geriatrics Society, 48: 1478-1482.
  41. Tractenberg, R. E., Patterson, M., Weiner, M.F., Teri, L., Grundman, M., Thomas, R. G., and Thal L. J. (2000). Prevalence of symptoms on the CERAD-Behavior Rating Scale for Dementia (BRSD): Normal elderly controls vs. Alzheimer's dementia patients. J Neuropsychiatry and Clin Neurosci, 12:4; 472-479.
  42. Weiner, M. F., Tractenberg, R. E., Teri, L., Logsdon, R. G., Thomas, R. G., and Thal, L. J. (2000). Quantifying agitated behaviors in Alzheimer's disease patients. Journal of Psychiatric Research; 34 (2, March): 163-167.
  43. Sano M., Albert S. M., Tractenberg R. E., Schittini, M. (1999). Developing utilities for stages of Alzheimer's disease using the Clinical Dementia Rating. Journal of Mental Health and Aging, 5: 59-68.

Chapters/Proceedings

Tractenberg RE, Singer CM. (2007). Sleep and Sleep Disturbance: from genes to dreams. Cellular and Molecular Life Sciences 64(10): 1171-1173.

Lungeanu D, Tractenberg RE and Mihalas GI. (2006). Developing an Interactive Approach in Teaching Medical Informatics. Proceedings of the 20th International Congress of the European Federation for Medical Informatics (August 2006). IOS Press.

Tractenberg, R. E., Weiner, M. F., R. G. Thomas, L. Teri, P. J. Whitehouse, and Thal, L. J. (2004). Prevalence of behavioral disturbance in Alzheimer’s disease. In B. Vellas, M. et al (Eds.) Research and Practice in Alzheimer’s Disease and Cognitive Decline. Vol 9, New York: Springer. Pp. 147-152.

Teri, L., Logsdon, R. G., Peskind, E., Raskind, M., Weiner, M. F., Tractenberg, R. E., et al. (2002). Treatment of agitation in Alzheimer's Disease: An investigation of haloperidol, trazodone and behavior management techniques. In Vellas B, Fitten J (Eds.), Research and Practice in Alzheimer’s disease and other dementias.Vol. 6. New York: Springer. Pp. 232-236.

Sano M., Albert S. M., Tractenberg R. E., Schittini, M. (2000). Developing utilities: Quantifying Quality of life for stages of Alzheimer's disease as measured by the Clinical Dementia Rating. In SM Albert and RG Logsdon, (Eds) Assessing Quality of Life in Alzheimer's Disease, New York: Springer 5: 81-91.

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Yun-Ling Zheng, PhD
Assistant Professor

Contact Information
LL Lombardi
NetID: yz37
Telephone: (202) 687-6654

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